openFrame Microscope

Modular, extensible, easily-maintained, open-source microscope platform

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The openFrame is a compact, modular, open-source microscope conceived by Paul French and developed with colleagues from the Photonics Group at Imperial College London, and designed, supported, and extended in collaboration with Cairn Research. The fundamental building blocks for self-builders are open source and can be purchased directly from Cairn, or machined in your own workshop based on the STEP files provided on, Photonics Group.

Alternatively Cairn Research can design, build, and test a bespoke microscope for your specific application consisting of any pre-assembled and aligned openFrame layers, complete with a choice of light sources, images splitters, stages, cameras, software etc from Cairn or other manufacturers. We are committed to sustainability and will also seek to integrate any components that you may already have in the lab on redundant microscopes to save your hard-earned grant money and to avoid waste.

Application Usage

  • Wide-field fluorescence
  • Phase contrast
  • Fluorescence Lifetime Imaging (FLIM)
  • Simultaneous/ratiometric calcium and voltage imaging
  • High content imaging
  • Single molecule and super resolution STORM/PALM/SIM
  • Total Internal Reflection Fluorescence (TIRF)
  • Fluorescence Recovery After Photobleaching (FRAP) and optogenetics
  • Electrophysiology
  • Bioluminescence
  • Single Plane Illumination Microscopy (SPIM)
  • Containment labs (compact and easy to sterilise)
  • Polarisation studies (anisotropy)

Features and Benefits

  • Compact and stable
  • Can be reconfigured rapidly and easily for different applications
  • Supplied with infinity-corrected tube lens and objectives from multiple sources, including Olympus and Nikon
  • Simultaneous imaging with multiple cameras and large format sensors (>25mm diagonal)
  • Extensible, only buy (or build) what you need, as you need it
  • Sustainable, can be supported and maintained by any competent microscopist or technician
  • Direct interface with parts from other manufacturers (e.g. Thorlabs) for rapid development of new techniques
  • Brand agnostic, works with existing illuminators, cameras, stages, objectives, filters, and lenses from any manufacturer
  • Unrivalled access to optical train, laser pointer test kit available for alignment and validation
  • Easy to clean or autoclave
  • Transportable – suitable for tradeshows, teaching courses and secondments
  • No eye pieces – COVID-19 / multi-user friendly
  • Comprehensive turn-key bespoke microscopes, built to order on an open-source platform
  • Rapid development environment for exploitation of new techniques and technologies
  • Compact and affordable base for specialised and routine experimental needs
  • Scalable for high content acquisition, diagnostics or teaching
  • Stacked, modular design provides inherent stability and facilitates easy access to primary optical path

Research Examples

Coming Soon!

FAQ

Cairns’s design ethos is based on compatibility across a wide range of manufacturers. In the rare case where we do not have a compatible part, we have a custom design team available to provide a solution. 

We provide a comprehensive 12-month warranty on all our products.

We aim for a delivery time of 2-4 weeks. However, the specific delivery time will be confirmed at the point of order.

We offer full training and support across our entire product range. 

Yes, we have full custom design capabilities and a multidisciplinary team of scientists and engineers available to provide a solution that meets your needs. 

Our CellCams are supported in Micro-Manager. 

Customer Reviews

"The build quality of their equipment is excellent, and has proven both reliable and versatile in our lab’s day-to-day research; our Cairn equipment has provided years of dependable service."
Andrew James
“Over the past 20 years we have purchased a wide range of equipment from Cairn Research, ranging from several Optopatch amplifiers, OptoLED, Optosourse arc lamp and custom-made optical pathways for nanoscale measurements.”
Walter Marcotti
“What I love about this company is the quality and the reliability of every piece of equipment that I purchased. The instruments are made of high-grade materials (mostly aluminum for the optics components) and are intended for heavy everyday use in the laboratory. “
Andreas Werdich

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